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Seminar on "Key Intermediates in NHC-catalysis, Redox Neutral Carboxylation, Decarboxylation and Ni-catalyzed "

The Indian Institute of Technology organised a seminar on July 01, 2019. The details of the same are as follows:

Title: "Key Intermediates in NHC-catalysis, Redox Neutral Carboxylation, Decarboxylation and Ni-catalyzed"

Speaker: Dr. Veera Reddy Yatham, Division of Organic synthesis and process chemistry, CSIR-IICT Hyderabad

Day & Date: July 1, 2019

Venue: Seminar Room 350, Department of Chemistry 

Abstract:

N-heterocyclic carbenes catalyzed Umpolung of aldehydes involves the formation of several intermediates i.e. Breslow-intermediates (diamino enols), diamino dienols and azolium enolates. A part of the lecture was devoted to discussing key Intermediates in NHC-umpolung of aldehydes (Part-1), address the problems and the solutions in NHC-umpolung of enals.

Visible-light photocatalysis is a powerful tool to generate various chemical motifs under mild reaction conditions. Most of the chemical reactions are initiated by either Ir or Ru complexes via single electron transfer (SET) through Metal to Ligand Charge Transfer (MLCT). Also, recently, visible-light-induced Ligand to Metal Charge Transfer (LMCT) emerged as a robust alternative to generate radical species by the homolysis of the metal-ligand bond. In this part, the first example of redox neutral di-carbo functionalization of styrenes with carbon dioxide and with carbon radicals (which are generated through MLCT by Ir-complex) was discussed. Also, one example on how to utilize simple cerium chloride as a photocatalyst through LMCT to get valuable compounds from simple precursors and application of this methodology for the late-stage fictionalizations of drug candidates were discussed upon.

Most of the metal-catalyzed cross-coupling reactions were conducted by employing halo compounds as coupling partners. In this context of coupling partners, the abundance of alkylamines in pharmaceuticals and pre-clinical candidates makes them utilize as a coupling partner in cross-coupling arena which can add significant value to the synthetic community. In this part, a methodology on how to utilize these alkyl amines as carbon electrophile in coupling reactions and also application of this methodology for late fictionalization of amine-containing drugs were discussed.

About the speaker:

Prof. Veera Reddy Yatham is currently a Ramanujan Faculty at CSIR-IICT, Hyderabad. Prof. Reddy does research in the development of new synthetic methodologies using visible light. He has also worked as a post-doctoral researcher at prestigious institutions like University of Regensburg, ICIQ, Tarragona, Spain and University of Cologne.