Short-term
course on
Recent Development in Fermentation and Downstream
Processing
October
14 –17,2003
Introduction
Applications of
recent advances in molecular biology have vastly increased the scope of
biochemical engineering in process industry. Bioprocessing provides various
advantages such as extreme selectivity, low cost of downstream processing, operation
at ambient temperature and pressure, low energy requirements, etc. Currently,
majority of the bioprocesses have evolved through empirical methods. Also
downstream processing is important as far as cost of production is considered.
The production of purified biologically active components depends on the
effectiveness of the separation processes used. These compounds could be as
diverse as therapeutics, biocatalysts, food ingredients and other specialty
biochemicals.
Main challenges
ahead of biochemical engineers are:
1. Quantification and optimization
2. scale-up based on rational strategies
3. process control and operational
strategies, and
4. bioseperation for downstream processing.
This short-term
course will address these challenges and recent developments in fermentation as
well as downstream processing. Hands on session will provide exposure to a
completely controlled B.braun fermentor, Emmerson exit gas analyzer, Merck HPLC
system with UV-RI detectors in series.
Who Will Benefit
The course is designed for practitioners and R & D managers working in the field of fermentation technology and downstream processing. The course will also provide various novel ideas for emerging bio-based technologies.
Course Contents
Theory (Morning)
·
Basic chemical engineering concepts.
·
Bioreaction engineering: growth kinetics and models.
·
Bioreactor design & scale-up: Batch, fed-batch
& continuous operation.
·
Bioreactor configuration: Airlift, loop, in-situ separation, etc.
·
Engineering considerations for recombinant
products.
·
Downstream processing: Recent techniques and scale-up.
·
Bioprocess optimization & operating
strategies.
·
Instrumentation and control of bioprocesses;
recent advances in monitoring, fault diagnosis.
·
Intracellular reaction rate analysis; Kinetic
approach, metabolite balance technique, structures kinetic models,
stoichiometric modeling, pathway attenuation; Practical examples.
·
Genetic engineering, Genetic models, foreign
protein synthesis, plasmid stability, Applications.
Hands on session (Afternoons/evenings)
·
Fermentor operation and control.
·
Measurement of fermentor parameters.
·
Downstream processing units; cross flow
filtration, etc.
·
Analytical tools; HPLC, GC etc.
Faculty and their Area of Expertise
· Prof. A.K.Suresh: Reaction Engineering, Multiphase systems, Biochemical Engineering.
· Prof. Narayan Punekar: Microbial Biochemistry, Molecular Enzymology, Fungal Molecular Genetics and its Applications to Metabolic Engineering.
· Prof. KV.Venkatesh: Metabolic Flux and Elementary mode Analysis, Bioreaction Engineering, Bioprocess Development.
· Prof. Pramod Wangikar: Experimental and theoretical analysis of bioprocesses.
· Prof. A.M.Lali (UICT): Downstream Processing in Biotechnology, Advanced Topics in Adsorptive and Chromatographic Separations
· Prof. Santosh Noronha: Downstream processing, Recombinant technology
· Prof. Sharad Bhartiya: Modeling, Identification & control; Optimization; Controller performance monitoring; Fault diagnosis; Observer design
Schedule
The course is scheduled during October 14 –17,2003
Venue
Seminar Hall, 2nd Floor, IIT Guest house (for lectures) and Biosystems Engineering Lab, Department of Chemical engineering, I.I.T. Bombay Report at Guest house on first day.
Lodging and Boarding
Guesthouse facility on the campus is available for a limited number of participants on payment as per actuals and with advance request.
Course Fee & Registration
The course fee per
participant is Rs. 7,500/-. Each applicant will receive lecture notes, the cost
of which is included in the registration fee. This fee also includes coffee
breaks and working lunch during the course days.
Fill out the
attached registration form and mail it along with course fees to the course
coordinator. Fees must be paid by a demand draft drawn in the favour of
“Registrar, IIT Bombay (CEP A/c)”.
Kindly note that
no income tax is to be deducted at source from course fee payment, as I.I.T.
Bombay is exempt from the same.
APPLICATIONS MAY BE SENT SO AS TO REACH US NOT LATER THAN: October 7, 2003
Address all
correspondence to:
Prof.Pramod Wangikar
(Course Coordinator)
Dept.of Chemical Engineering,
Indian
Institute of Technology, Bombay,
Powai, Mumbai: 400 076
Tel :
25764215 (Mr.Prashant), 2576 7060 (CEP)
Grams :
Technology, Mumbai-76
Fax :
2572 6895, 2572 3480
Email :
pw-cep@che.iitb.ac.in
R E G I S T R A T I O N F O R M
Four-day Short Term Course on
RECENT DEVELOPMENT
IN FERMENTATION AND DOWNSTREAM PROCESSING
October 14 – 17, 2003
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DESIGNATION :
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Yrs.
IIT Guest House accommodation required?* YES / NO
(*Guest House
bill to be paid directly by participant.)
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